Macrolides:

Azithromycin

Clarithromycin

CNI (cyclosporine and tacrolimus)

Sirolimus

Increased levels of immunosuppressive agent (clarithromycin with more pronounced effect)

GI (nausea, vomiting, diarrhea)

Decreased hearing

Hepatitis

Clinical symptoms

Periodic LFTs during first 2-3 months

CNI and sirolimus levels

Rifamycins:

Rifampin

Rifabutin

CNIs 

Sirolimus

Corticosteroids

Mycophenolate

Decreased levels of immunosuppressive agent

Hepatitis

Orange discoloration of urine

GI effects

Hypersensitivity (rash, fever)

Flu-like syndrome

Hematologic (leucopenia, granulocytopenia)

Clinical symptoms

Periodic CBC, LFTs

CNI and sirolimus levels

Ethambutol

None

Optic neuritis

Periodic testing for red/green color discrimination and visual acuity

Clinical symptoms

Fluoroquinolones:

Ciprofloxacin

Levofloxacin

Moxifloxacin

CNI

sirolimus

Increased level of immunosuppressive medication (mild)

GI effects

Tendonitis and tendon rupture

CNS (headache, insomnia, agitation)

Photosensitivity

QT prolongation

Clinical symptoms

CNI and sirolimus levels

Tetracyclines:

Minocycline

Doxycycline

None

GI effects

Photosensitivity

Vertigo, dizziness

Increased LFTs

Clinical symptoms

Tigecycline

None

GI effects

Photosensitivity

Vertigo, dizziness

Increased LFTs

Clinical symptoms

Tobramycin

Amikacin

Streptomycin

CNIs 

Increased risk of nephrotoxicity

Nephrotoxicity

Vestibular and auditory toxicity (dizziness, vertigo, ataxia, tinnitus, hearing loss)

Clinical symptoms

Periodic serum creatinine measurements

Baseline and periodic hearing tests in high risk individuals

Isoniazid

None

Hepatitis

Hypersensitivity (rash, fever)

Neurotoxicity

Periodic LFTs

Clinical symptoms

Linezolid

No interactions with immunosuppressants

interaction with serotonergic agents (many antidepressants) can result in serotonin syndrome

Myelosuppressive (leukopenia, anemia, thrombocytopenia)

Optic neuropathy

Peripheral neuropathy

Periodic CBC.

Clinical symptoms